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Ribonucleoprotein particle : ウィキペディア英語版 | Ribonucleoprotein particle
A ribonucleoprotein particle or RNP is a complex formed between RNA and RNA-binding proteins (RBPs). The term 'RNP foci' is also used to denote an intracellular compartment involved in processing of RNA transcripts. == RNA/RBP complexes ==
RBPs interact with RNA through binding motifs. Aromatic amino acid residues in this RNA binding motif result in stacking interactions with RNA. Lysine residues in the helical portion of RNA binding proteins help to stabilize interactions with nucleic acids. This nucleic acid binding is a result of the force of attraction between the positive electrical charge of lysine side chains and the negative electrical charge of nucleic acid phosphate backbones. It is hypothesized that RNA sequences, called elements, in the 3'-untranslated region determine the binding of RBPs, and that these RBPs determine the post-transcriptional fate of mRNAs.
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